Protein Chemistry Scientist / Project Leader, PhD level

Metabomed

posted: 19/12/2021

Job description:

Protein Chemistry Scientist / Project Leader with Cell Biology experience

Metabomed, a clinical stage cancer drug-discovery biotech company, seeks an
enthusiastic, experienced Protein Chemistry Scientist with Cell Biology experience
to join our R&D team in Yavne. The position is for a hands-on senior scientist with
a PhD in life science that will be responsible for conducting biological experiments
as part of an effort to discover and develop new cancer therapeutics.

As a member of an interdisciplinary team, this individual will be expected to employ
proteomics approaches to support target identification/deconvolution, target
engagement, and mode–of–action (MOA) elucidation efforts in several drug
discovery programs.

Required qualifications:

Ph.D. in Biochemistry, Cell-biology, or related discipline with relevant experience.
Experience with chemical-affinity enrichment to selectively enrich proteins and chemical biology techniques using probes (covalent and/or photoaffinity).
Experiences with Stable isotope labeling with amino acids (SILAC) or other quantitative proteomics techniques is an advantage.
Experience in isolating protein from complex biological samples and sample processing workflow for LC-MS analysis.
Experience in conducting, analyzing and interpreting LC-MS/MS proteomics data is an advantage.

Functions and Duties

Lead and contribute to developing and implementing proteomic
technologies to investigate target identification / deconvolution of small-
molecule compounds identified from screens.
Perform cell-based proteome profiling studies to support target
identification, target engagement, and mode-of-action (MOA) elucidation
efforts in multiple drug discovery programs.
Design and execute experiments independently; accurately record,
analyze and present results.
Collaborate with CROs and academic labs to compliment internal
proteomic/chemical biology capabilities.

Job location

Yavne