We are looking for applicants who will perform state-of-the-art computational analyses of genomic profiling data to reveal deficiencies in DDR pathways in cohorts of HNSCC patients from Inselspital, Bern. This will include DDR-related mutational signatures and homologous recombination deficiency scores of HNSCC tissues, including primary, locally advanced, as well as recurrent samples and patient-derived cell lines. Other publicly available cohorts will be analyzed analogously to strengthen our results. The applicant will also use preclinical in vitro HNSCC models to evaluate the efficacy of therapies that target specific DDR molecular players alone and in combination with standard HNSCC therapies including radiotherapy, cisplatin, and cetuximab. In this way, this project will bridge the gap between genomic analysis and the translation of research into clinical testing.
PhD position in cancer biology: DNA damage response deficiencies in head and neck squamous cell carcinoma
- posted: 20/11/2023
About the company:
We are looking for applications from outstanding candidates who hold an MSc. degree in Biostatistics, Biology, or Biochemistry. Applicants should have strong analytical skills, programming experience, and fluency in English. Practical background in molecular and cellular laboratory techniques (2D and 3D cell cultures, proliferation assays, fluorescence microscopy) serves as an advantage.
The applicants should be able to work independently as well as in a team, have critical thinking, good organizational skills, and a deep interest in research.
We offer an attractive and friendly international working environment and an opportunity to actively develop the project with clinical applications. All our students are enrolled in the Graduate School for BioMedical and Cellular Science, University of Bern (www.gcb.unibe.ch), which offers an excellent academic framework (seminars, workshops, journal clubs, networking opportunities, etc.).