Conservation of cis-regulatory elements across plant families

Hebrew University

About the institute:

This is a collaborative project between the Friedlander and Efroni labs in the Hebrew University (Rehovot campus). The two labs offer a combination of experimental and computational expertise. Research will be conducted in the Rehovot campus, but partial remote work is also possible.

Institute description:

Many genes have deeply conserved functions and expression patterns across plant families, implying deep conservation of cis-regulatory control. While gene sequences are easily annotated, deciphering the location and function of the cis-regulatory elements (CREs) controlling when, where, and to what levels genes are expressed remains challenging. Specifically, plant genomes are highly dynamic and algorithms previously developed for animal genomes are not suitable for plants.
If identified, plant CREs can be later used as targets for genomic editing, holding great promise for future crop improvement.
The suggested project will develop a new approach to identify deeply conserved CREs across angiosperms, which will serve as targets for future crop improvement.

The position is currently offered for 1-year with possible extension upon mutual agreement.

Informal enquiries are also welcome.

Required qualifications:

Candidates should have a PhD in either bioinformatics, computational biology or computer science (or related fields) with experience in usage of bioinformatics tools and good programming skills.
The position is available immediately.

Institute location: