Computational Drug Discovery Scientist / Protein Engineering


About the company:

Trojan-bio, a leading biotech innovator based in Yavne, Israel, is dedicated to revolutionizing cancer treatment through the development of cutting-edge bi-functional antibodies. Join our dynamic R&D team and play a pivotal role in shaping the future of immunotherapy.

Job description:

We are seeking an experienced antibody/protein engineer to facilitate our R&D efforts. As a key member of our multidisciplinary team, you will drive the discovery, design, and optimization of novel immunotherapy modalities using state-of-the-art computational and structural methods.
Key Responsibilities:
Lead the implementation of cutting-edge structural methods, including molecular dynamics simulations, homology modelling, and docking studies, to design breakthrough drug candidates.
Harness AI/ML approaches and Antibody/Protein Engineering techniques to discover and optimize therapeutic antibodies.
Stay abreast of emerging technologies in structural biology and integrate novel approaches into our research programs to maintain our competitive edge.
Collaborate closely with laboratory personnel and Contract Research Organizations (CRO) to oversee antibody expression, quality control, and efficacy testing.
Contribute to project planning, scheduling, and cost estimation, ensuring timely and cost-effective delivery of assigned projects.
Foster a culture of collaboration and excellence by building effective working relationships with colleagues, management, and external partners.

Required qualifications:

PhD in Computational Structural Biology, Bioinformatics, or a related field. (Or Ms.C with extensive relevant industrial record)
Minimum of 3 years' experience in designing or optimizing novel proteins or antibodies.
Proficiency in molecular modelling, simulation, and visualization packages.
Expertise in computational biology, including AI/ML approaches and bioinformatics tools (e.g., AlphaFold, ESM, Rosetta), with experience in Linux and cloud environments and proficiency in Python.
Proven ability to manage multiple projects simultaneously in a fast-paced, milestone-driven environment.
Strong oral and written communication skills, with experience presenting scientific data to diverse audiences.

Job location

Yavne, Israel